000			05702cam a2200661Mu 4500
005			20250919213640.0
006			m o d
007			cr un|nnnaucun
008			171212s2014 xx o 000 0 eng d
020			_a9781118870914 _q(electronic bk.)
020			_a1118870913 _q(electronic bk.)
020			_a9781118870921
020			_a1118870921
029	1		_aDEBBG _bBV043397197
029	1		_aDEBSZ _b431794553
029	1		_aNZ1 _b15913655
035			_a(OCoLC)892799105
035			_a(OCoLC)ocn892799105
039		9	_a201902141132 _bmurni _y12-12-2017 _zhafiz _wMYUKM (1).mrc _x637
040			_aEBLCP _beng _epn _cEBLCP _dOCLCO _dIDEBK _dDG1 _dHEBIS _dRECBK _dDEBSZ _dOCLCQ _dOCLCF _dDEBBG _dOCLCQ
049			_aMAIN
050		4	_aQR189
082	0	4	_a615.3 _a615.3/72
100	1		_aWen, Emily P.
245	1	0	_aVaccine Development and Manufacturing.
260			_aHoboken : _bWiley, _c2014.
300			_a1 online resource (1044 pages).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aWiley Series in Biotechnology and Bioengineering
500			_a9.5 Equipment.
505	0		_aCover; Series; Title Page; Copyright; Acknowledgments; Preface; Contributors; Chapter 1: History of Vaccine Process Development; 1.1 Introduction; 1.2 Vaccines Bioprocess Evolution; 1.3 Live Attenuated and Inactivated Virus Vaccines; 1.4 Live or Whole-Killed Bacterial Vaccines; 1.5 Classical Subunit Vaccines; 1.6 Recombinant Subunit Vaccines; 1.7 Conjugate Vaccines; 1.8 Downstream Processing; 1.9 Vaccines for the Developing World: Large Volume, Low Cost, and Thermostable; 1.10 Summary; Acknowledgments; References.
505	8		_aChapter 2: The Production of Plasmid DNA Vaccine in Escherichia coli: A Novel Bacterial-Based Vaccine Production Platform2.1 Introduction: E. coli in Vaccine Production; 2.2 Brief Overview of DNA Vaccines: Mechanisms and Methods of Vaccinations; 2.3 Current Status of DNA Vaccines; 2.4 Required Physical Properties of Plasmid DNA Vaccines; 2.5 Choice of E. coli Host Strain; 2.6 Factors Influencing Plasmid Stability; 2.7 Transformation, Selection of Producing Clones, and Cell Banking; 2.8 Production Process; 2.9 Requirements for Clinical Supplies; 2.10 Conclusions; References.
505	8		_aChapter 3: Fungal Expression Systems for Vaccine Production3.1 Introduction; 3.2 Hepatitis B Vaccines; 3.3 Human Papillomavirus Vaccine; 3.4 Malaria Vaccine Candidates; 3.5 HIV Vaccine Candidates; 3.6 Veterinary Vaccines; 3.7 Perspectives; 3.8 Concluding Remarks; Acknowledgments; References; Chapter 4: Novel Expression Systems for Vaccine Production; 4.1 Introduction; 4.2 Subunit Vaccines; 4.3 Expression Systems; 4.4 Novel Expression Systems; 4.5 Production of Recombinant Proteins in Plants; 4.6 Launch Vector System; 4.7 Conclusions; References; Chapter 5: Viral Vaccines Purification.
505	8		_a5.1 Introduction5.2 Process Tasks; 5.3 Conclusions and Outlook; Acknowledgments; Nomenclature; Abbreviations; References; Chapter 6: Protein Subunit Vaccine Purification; 6.1 Introduction; 6.2 Purification Technologies-Applications in Protein Subunit Vaccine Purification; 6.3 Purification Process Development and Scale-Up for Protein Subunit Vaccine; 6.4 Process Definition Studies; 6.5 Process Economy and Automation; 6.6 Application of Process Analytical Technology in Protein Purification; 6.7 Downstream Purification-An Outlook; References; Chapter 7: Conjugate Vaccine Production Technology.
505	8		_a7.1 Conjugate Vaccine Production Technology7.2 Preparation of Antigen and Carrier Protein; 7.3 Polysaccharide Size; 7.4 Activation and Coupling of Polysaccharide and Carrier Protein; 7.5 Characterization of the Conjugate; 7.6 Future Directions; References; Chapter 8: Stabilization and Formulation of Vaccines; 8.1 Introduction; 8.2 An Example of a Modern Vaccine Characterization Strategy; 8.3 A Comprehensive Approach to Vaccine Formulation in Practice; 8.4 Conclusions; References; Chapter 9: Lyophilization In Vaccine Processes; 9.1 Introduction; 9.2 Formulation; 9.3 Filling; 9.4 Lyophilization.
520			_aVaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high.
588	0		_aPrint version record.
650		0	_aVaccines _vLaboratory manuals.
650		4	_aVaccines _xLaboratory manuals.
650		4	_aVaccines.
650		7	_aVaccines. _2fast _0(OCoLC)fst01163573
655		4	_aElectronic books.
655		7	_aLaboratory manuals. _2fast _0(OCoLC)fst01920776
700	1		_aEllis, Ronald.
700	1		_aPujar, Narahari S.
773	0		_tWiley e-books
776	0	8	_iPrint version: _aWen, Emily P. _tVaccine Development and Manufacturing. _dHoboken : Wiley, ©2014 _z9780470261941
830		0	_aWiley series in biotechnology and bioengineering.
856	4	0	_uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=http://onlinelibrary.wiley.com/book/10.1002/9781118870914 _zWiley Online Library
907			_a.b16543774 _b2022-11-02 _c2019-11-12
942			_n0
914			_avtls003629309
998			_ae _b2017-12-12 _cm _dz _feng _gxx _y0 _z.b16543774
999			_c691321 _d691321