| 000 | 02588cam a22003738i 4500 | ||
|---|---|---|---|
| 008 | 200603s2021 nju b 001 0 eng | ||
| 020 |
_a9783527347285 _q(hardback) _cRM616.25 (PTSL) _cRM614.80 (PPUKM) |
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| 040 |
_aDLC _beng _erda _cDLC _dUKM _erda |
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| 042 | _apcc | ||
| 090 |
_aQP551 _b.L643 |
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| 090 |
_aQP551 _b.L856 2021 9HUKM |
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| 245 | 0 | 0 |
_aLong-lived proteins in human aging and disease / _cedited by Roger Truscott. |
| 264 | 1 |
_aHoboken, NJ : _bWiley, _c[2021] |
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| 264 | 4 | _c©2021. | |
| 300 |
_ax, 209 pages : _billustrations ; _c25 cm. |
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| 336 |
_atext _2rdacontent |
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| 337 |
_aunmediated _2rdamedia |
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| 338 |
_avolume _2rdacarrier |
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| 504 | _aIncludes bibliographical references and index. | ||
| 520 |
_a'While most proteins in the human body are short-lived and are constantly being regenerated, this is not true for all. A significant fraction of proteins in long-lived cells such as nerve cells are likewise long-lived and will age over time by accumulating damage and other modifications. Scientists are only beginning to understand how this aging of long-lived proteins contributes to age-dependent diseases such as dementia and cancer Divided into six major sections, this comprehensive overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. Analytical methods to study protein half-life and the accumulation of modifications are presented, followed by several examples of long-lived proteins found in humans and other organisms. Next, the molecular mechanisms of aging on the protein level are described, in particular the most common side chain modifications, followed by a discussion of the consequences of protein aging on cellular and organ function. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed'-- _cProvided by publisher. |
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| 650 | 2 |
_aAging _xMolecular aspects. |
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| 650 | 2 | _aProteins. | |
| 650 | 2 |
_aCells _xAging. |
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| 650 | 2 |
_aAging _xPhysiological aspects. |
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| 700 | 1 |
_aTruscott, Roger J. W., _eeditor. |
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| 907 |
_a.b16874961 _b2022-04-20 _c2021-08-30 |
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| 942 |
_c01 _n0 _kQP551 .L643 |
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| 949 |
_o101017441 _o101012941 (PPUKM) |
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| 990 | _aros/salmah/Rizal | ||
| 991 | _aINBIOSIS | ||
| 991 | _aJabatan Perubatan, PPUKM. | ||
| 998 |
_at _ah _b2021-08-30 _cm _da _feng _gnju _y0 _z.b16874961 |
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| 999 |
_c654781 _d654781 |
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