000			04677cam a2200661Ii 4500
001			ocn999588293
005			20250919141839.0
006			m o d
007			cr |n|||||||||
008			170804s2017 gw ob 001 0 eng d
020			_a9783527699131 _q(electronic bk.)
020			_a3527699139 _q(electronic bk.)
020			_a9783527699124 _q(electronic bk.)
020			_a3527699120 _q(electronic bk.)
020			_z3527340866
020			_z9783527340866
029	1		_aCHVBK _b495227986
029	1		_aCHNEW _b000964933
029	1		_aDEBSZ _b494212101
035			_a(OCoLC)999588293 _z(OCoLC)998785567 _z(OCoLC)1000037842 _z(OCoLC)1002125199
040			_aYDX _beng _cYDX _dNST _dIDEBK _dEBLCP _dNLE _dOCLCO _dDG1 _dOCLCQ _dNST _dRECBK _dOCLCF _dUAB _dUPM _dDEBSZ
049			_aMAIN
050		4	_aRM666.P87
072		7	_aMED _x071000 _2bisacsh
082	0	4	_a615.3 _223
245	0	0	_aProtein therapeutics _h[electronic resource] / _cedited by Tristan Vaughan, Jane Osbourn, and Bahija Jallal.
260			_aWeinheim, Germany : _bWiley-VCH, _c[2017]
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aMethods and principles in medicinal chemistry ; _vv. 71
504			_aIncludes bibliographical references and index.
520			_aIn this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.
505	0		_aCover ; Title Page ; Copyright ; Contents; Preface ; A Personal Foreword ; Acknowledgments ; Volume 1; Part I Introduction to Protein Therapeutics: Past and Present ; Chapter 1 Early Recombinant Protein Therapeutics ; 1.1 Introduction ; 1.2 The Birth of Genetic Engineering
505	8		_a1.3 Recombinant Human Insulin 1.3.1 The Race to Clone the Human Insulin Gene and to Produce Human Recombinant Insulin ; 1.3.2 Novo's Counter Strategy: Semisynthetic Human Insulin ; 1.3.3 Yeast Recombinant Insulin ; 1.4 Recombinant Human Growth Hormone ; 1.5 Recombinant Human Interferons
505	8		_a1.6 Recombinant Human Erythropoietin 1.7 Recombinant Tissue -- Type Plasminogen Activator ; 1.8 Recombinant Hepatitis B Virus (HBV) Vaccine ; 1.9 Postscript ; Acknowledgments ; References ; Chapter 2 Evolution of Antibody Therapeutics
505	8		_a2.1 Overview of Antibody Therapeutics Development 2.2 Polyclonal Antibodies -- Laying the Foundation for mAb Therapy ; 2.3 Evolution of Monoclonal Antibody Therapeutics ; 2.3.1 Chimeric and Humanized mAbs ; 2.3.2 Fully Human Antibodies ; 2.4 Fc Fusion Proteins
505	8		_a2.5 Evolution of Concepts in Antibody Pharmacology 2.5.1 Neutralization ; 2.5.2 From Killing Bacteria to Killing Human Cells ; 2.5.3 Targeting Membrane Receptors ; 2.6 Future Directions for Antibody Therapeutics Development ; Acknowledgments ; References
650		0	_aProtein drugs.
650		0	_aProteins _xTherapeutic use.
650		7	_aMEDICAL / Pharmacology _2bisacsh
650		7	_aProtein drugs. _2fast _0(OCoLC)fst01079679
650		7	_aProteins _xTherapeutic use. _2fast _0(OCoLC)fst01079767
655		4	_aElectronic books.
655		0	_aElectronic books.
700	1		_aVaughan, Tristan, _eeditor.
700	1		_aOsbourn, Jane, _eeditor.
700	1		_aJallal, Bahija, _eeditor.
776	0	8	_cOriginal _z3527340866 _z9783527340866 _w(OCoLC)988760633
830		0	_aMethods and principles in medicinal chemistry ; _vv. 71.
856	4	0	_uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9783527699124 _zWiley Online Library
907			_a.b16816699 _b2022-11-02 _c2020-07-17
942			_n0
998			_ae _b2020-07-17 _cm _dz _feng _ggw _y0 _z.b16816699
999			_c649078 _d649078