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008 150226s2015 gw ob 001 0 eng d
020 _a9783527680658
_qelectronic bk.
020 _a3527680659
_qelectronic bk.
020 _a9783527680665
_qelectronic bk.
020 _a3527680667
_qelectronic bk.
020 _z9783527337194
020 _a3527337199
020 _a9783527337194
020 _a9783527680672 (Epub)
020 _a3527680675 (Epub)
020 _a9783527680689 (mobi)
020 _a3527680683 (mobi)
029 1 _aCHVBK
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029 1 _aNZ1
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029 1 _aDEBSZ
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035 _a(OCoLC)904046276
_z(OCoLC)961646872
_z(OCoLC)962625293
040 _aNST
_beng
_erda
_epn
_cNST
_dNST
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049 _aMAIN
050 4 _aQH438.4.B55
072 7 _aSCI
_x007000
_2bisacsh
082 0 4 _a572.86
_223
245 0 0 _aBiomarker validation :
_btechnological, clinical and commercial aspects /
_cedited by Harald Seitz and Sarah Schumacher.
264 1 _aWeinheim, Germany :
_bWiley-VCH,
_c2015.
300 _a1 online resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
588 0 _aVendor-supplied metadata.
504 _aIncludes bibliographical references and index.
505 0 _aRelated Titles; Title Page; Copyright; Table of Contents; List of Contributors; Chapter 1: Biomarkers -- Past and Future; 1.1 Introduction; 1.2 Definitions of Biomarkers; 1.3 Biomarkers in the Past; 1.4 Novel Molecules and Structural Classes of Biomarkers by New Technologies; 1.5 Biomarkers in Drug Research; 1.7 Summary and Outlook; References; Chapter 2: Quantitative Proteomics Techniques in Biomarker Discovery; 2.1 Introduction; 2.2 2D-Difference Gel Electrophoresis; 2.3 Mass Spectrometry-Based Proteomics; 2.4 MALDI Mass Spectrometry Imaging; 2.5 Conclusion; References
505 8 _aChapter 3: Biomarker Qualification: A Company Point of View3.1 Introduction; 3.2 Biomarker Uses; 3.3 Biomarker Types; 3.4 Validation vs. Qualification; 3.5 Strategic Choices in Business Models; 3.6 Validation of Analytical Methods; 3.7 Clinical Qualification of Candidate Biomarkers; 3.8 Biomarker Qualification in the'omics Era; 3.9 An Example of a Biomarker Provider; 3.10 Conclusion; References; Chapter 4: Biomarker Discovery and Medical Diagnostic Imaging; 4.1 Introduction; 4.2 Factors to Consider in Biomarker Selection for Imaging
505 8 _a4.3 Defining the Insertion Point of the Assay and Its Business Case4.4 Practical In Vitro Methods Used to Identify Biomarkers; 4.5 Preclinical Models; 4.6 Preclinical Analysis Techniques; 4.7 Translational Considerations and Restrictions; 4.8 Other Uses of Preclinical Models; 4.9 Nuclear Imaging Infrastructure; 4.10 Image Processing; 4.11 Concluding Remarks; References; Chapter 5: Breath: An Often Overlooked Medium in Biomarker Discovery; 5.1 Introduction; 5.2 Breath Analysis Studies: Targets, Techniques, and Approaches; 5.3 Biomarker Confounders; 5.4 Biomarkers in Breath
505 8 _a5.5 Outlook for Breath AnalysisAcknowledgments; References; Chapter 6: HTA in Personalized Medicine Technologies; 6.1 Introduction; 6.2 Health Technology Assessment (HTA); 6.3 Validation and Evaluation of Biomarker Tests; 6.4 Health Technology Assessment of Personalized Medicine Technologies; 6.5 Concluding Remarks; References; Chapter 7: Bone Remodeling Biomarkers: New Actors on the Old Cardiovascular Stage; 7.1 Introduction; 7.2 Cardiovascular Disease and Osteoporosis: Common Risk Factors and Common Pathophysiological Mechanisms; 7.3 Biomarkers of Bone Health in CVD; 7.4 Conclusion
650 0 _aBiochemical markers.
655 4 _aElectronic books.
655 7 _aElectronic books.
_2local
655 0 _aElectronic books.
700 1 _aSeitz, Harald,
_eeditor.
700 1 _aSchumacher, Sarah,
_eeditor.
776 0 8 _iPrint version:
_w(OCoLC)ocn904046276
_z9783527680658
856 4 0 _uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9783527680658
_zWiley Online Library
907 _a.b16816407
_b2022-10-06
_c2020-07-17
942 _n0
998 _ae
_b2020-07-17
_cm
_dz
_feng
_ggw
_y0
_z.b16816407
999 _c649049
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