000			04553cam a2200709 i 4500
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006			m o d
007			cr |||||||||||
008			190918s2015 nju ob 001 0 eng
010			_a2015-011278
015			_aGBB619243 _2bnb
020			_a9781118838419 (pdf)
020			_a1118838416 (pdf)
020			_a9781118838327 (epub)
020			_a1118838327 (epub)
020			_z9781118838273 (cloth)
020			_a9781118838440
020			_a1118838440
028	0	2	_aEB00665390 _bRecorded Books
029	1		_aAU@ _b000054463429
029	1		_aDEBBG _bBV043397637
035			_a(OCoLC)905450321 _z(OCoLC)934935697 _z(OCoLC)966176713
035			_a(OCoLC)ocn905450321
037			_a9781118838327 _bWiley
039		9	_a201911051411 _bmurni _y09-18-2019 _zhafiz _wUKM UBCM Wiley MARC (363 titles).mrc _x308
040			_aDLC _beng _erda _cDLC _dNST _dIDEBK _dYDXCP _dCDX _dDG1 _dEBLCP _dNLE _dDEBBG _dKSU _dRECBK _dOCLCO _dCCO _dOCLCA
042			_apcc
049			_aMAIN
050	0	0	_aRM301.5
060	1	0	_aQV 771
072		7	_aMED _x071000 _2bisacsh
082	0	0	_a615.7 _223
100	1		_aYanni, Souzan, _eauthor.
245	1	0	_aTranslational ADMET for drug therapy : _bprinciples, methods, and pharmaceutical applications / _cSouzan Yanni.
264		1	_aHoboken, New Jersey : _bJohn Wiley & Sons, Inc., _c[2015]
300			_a1 online resource.
336			_atext _2rdacontent
337			_acomputer _2rdamedia
338			_aonline resource _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aTranslational Concept and Determination of Drug Absorption -- Distribution: Principle, Methods, and Applications -- Metabolism: Principle, Methods, and Applications -- Excretion: Principle, Methods, and Applications for Better Therapy -- Drug-Drug Interaction: From Bench to Drug Label -- General Toxicology: Principle, Methods, and Applications -- Toxicokinetics and Toxicity Testing in Drug Development -- PBPK Modeling and In Silico Prediction for ADME and Drug-Drug Interaction -- Translational Tools toward Better Drug Therapy in Human Populations -- Phase 1-Phase 3 Clinical Studies, Procedures, Responsibilities, and Documentation -- Regulatory Submission: MIST and Drug Safety Assessment.
506			_aOwing to Legal Deposit regulations this resource may only be accessed from within National Library of Scotland. For more information contact enquiries@nls.uk. _5StEdNL
520			_aServing as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations. -Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations -Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage -Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines -Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies -Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval.
588			_aDescription based on print version record and CIP data provided by publisher.
650		0	_aPharmacokinetics.
650		0	_aDrugs _xMetabolism _xPharmacokinetics.
650		2	_aDrug Evaluation, Preclinical.
650		2	_aPharmacokinetics.
650		2	_aDrug-Related Side Effects and Adverse Reactions.
650		2	_aPharmaceutical Preparations _xmetabolism.
650		4	_aMedical.
655		4	_aElectronic books.
773	0		_tWiley e-books
776	0	8	_iPrint version: _aYanni, Souzan, author. _tTranslational ADMET for drug therapy _dHoboken, New Jersey : John Wiley & Sons, Inc., [2015] _z9781118838273 _w(DLC) 2015010195
856	4	0	_uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9781118838440 _zWiley Online Library
907			_a.b16758067 _b2022-09-26 _c2019-11-12
942			_n0
914			_avtls003651463
998			_ae _b2019-05-09 _cm _dz _feng _gnju _y0 _z.b16758067
999			_c643693 _d643693