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020 _a9781119305163
_q(electronic bk.)
020 _a1119305160
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020 _a9781119305101
_q(electronic bk.)
020 _a1119305101
_q(electronic bk.)
020 _z9781119305149
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029 1 _aCHNEW
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035 _a(OCoLC)1039079208
035 _a(OCoLC)on1039079208
039 9 _a201911011148
_bros
_y09-18-2019
_zhafiz
_wUKM UBCM Wiley MARC (363 titles).mrc
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040 _aNST
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049 _aMAIN
050 4 _aRM151
060 4 _aWB 340
072 7 _aMED
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082 0 4 _a615.6
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245 0 0 _aMicroneedles for drug and vaccine delivery and patient monitoring /
_cedited by Ryan F. Donnelly, Thakur Raghu Raj Singh, Eneko Larrañeta, and Maelíosa T.C. McCrudden.
264 1 _a[Place of publication not identified] :
_bJohn Wiley and Sons, Inc. :
_bWiley,
_c2018.
300 _a1 online resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aCover; Title Page; Copyright; Contents; List of Contributors; About the Editors; Preface; Chapter 1 Genesis of Transdermal Drug Delivery; 1.1 Skin Anatomy; 1.1.1 The Epidermis; 1.1.2 The Stratum Corneum; 1.1.3 The Dermis; 1.1.4 Skin Appendages; 1.2 Routes to Percutaneous Drug Absorption; 1.3 Facilitated Transdermal Drug Delivery; 1.3.1 Electrical-based Devices; 1.3.1.1 Iontophoresis; 1.3.1.2 Electroporation; 1.3.1.3 Ultrasound; 1.3.1.4 Cryopneumatic and Photopneumatic Technologies; 1.3.1.5 Velocity-based Devices; 1.3.1.6 Thermal Approaches (Lasers and Radiofrequency Heating)
505 8 _a1.3.1.7 MicroneedlesReferences; Chapter 2 Microneedle Manufacturing and Testing; 2.1 Introduction; 2.2 Material Types, Properties and Biocompatibility; 2.2.1 Silicon; 2.2.1.1 Biocompatibility of Silicon; 2.2.2 Metals; 2.2.2.1 Biocompatibility of Metals; 2.2.3 Ceramics; 2.2.3.1 Biocompatibility of Ceramics; 2.2.4 Silica Glass; 2.2.4.1 Biocompatibility of Silica Glass; 2.2.5 Carbohydrates; 2.2.5.1 Biocompatibility of Carbohydrates; 2.2.6 Polymers; 2.2.6.1 Biocompatibility of Polymers; 2.3 Microneedles Manufacturing and Design; 2.3.1 Basics of Microfabrication; 2.3.1.1 Lithography and Etching
505 8 _a2.3.1.2 Thin-film Deposition on Substrates2.3.1.3 Etching; 2.3.2 Microfabrication MNs; 2.3.2.1 Fabrication of Silicon MNs; 2.3.2.2 Fabrication of Metal and Glass MNs; 2.3.2.3 Fabrication of Polymeric MNs; 2.3.3 Microneedle Design; 2.4 Microneedle Mechanical Characterisation; 2.4.1 Axial Force Microneedle Mechanical Tests; 2.4.2 Transverse Force and Shear Strength Microneedle Mechanical Tests; 2.4.3 Baseplate Strength and Flexibility Tests; 2.4.4 Microneedle Insertion Measurements; 2.4.4.1 Staining of Microneedle-treated Skin; 2.4.4.2 Transepidermal Water Loss Measurements
505 8 _a2.4.4.3 Electrical Impedance Measurements2.4.4.4 Histological Tissue Staining and Sectioning; 2.4.4.5 Confocal Microscopy; 2.4.4.6 Optical Coherence Tomography; 2.4.5 Significance of Microneedle Test Results; References; Chapter 3 Microneedle-mediated Drug Delivery; 3.1 Introduction; 3.2 Microneedle Drug Delivery Strategies; 3.2.1 Solid Microneedles; 3.2.2 Coated Microneedles; 3.2.3 Hollow Microneedles; 3.2.4 Dissolving Microneedles; 3.2.5 Hydrogel-forming Microneedles; 3.3 Conclusion; References; Chapter 4 Microneedle-mediated Vaccine Delivery; 4.1 Introduction; 4.2 Vaccine Delivery
505 8 _a4.2.1 Vaccination4.2.2 Alternative Vaccine Delivery Options; 4.3 Intradermal Vaccination; 4.3.1 Skin Structure; 4.3.2 Skin Immune Response; 4.3.3 Conventional Strategies for Intradermal Vaccine Delivery; 4.4 MN Delivery of Vaccine Therapeutics; 4.4.1 Dissolving/Biodegrading Polymeric MNs; 4.4.1.1 Viral Vaccines; 4.4.1.2 Bacterial Vaccines; 4.4.1.3 Model and Novel Vaccines; 4.4.2 Hollow MNs; 4.4.3 Solid MN; 4.4.3.1''Poke and Patch'' Methodologies; 4.4.3.2 Coated MNs; 4.5 Future Perspectives; References
520 _aProvides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications. Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry. -The only book currently available on microneedles -Filled with tables, graphs, and black and white images (photographs, micrographs) -Authored by four experts in pharmaceutics Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.
588 0 _aOnline resource; title from PDF title page (EBSCO, viewed June 11, 2018).
650 0 _aTransdermal medication.
650 0 _aPatient monitoring
_xEquipment and supplies.
650 0 _aNanomedicine.
650 0 _aVaccines.
650 2 _aDrug delivery systems.
655 4 _aElectronic books.
700 1 _aDonnelly, Ryan F.,
_eeditor.
700 1 _aSingh, Thakur Raghu Raj,
_eeditor.
700 1 _aLarrañeta, Eneko,
_eeditor.
700 1 _aMcCrudden, Maelíosa T.C.,
_eeditor.
773 0 _tWiley e-books
856 4 0 _uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9781119305101
_zWiley Online Library
907 _a.b16754980
_b2022-10-04
_c2019-11-12
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998 _ae
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