Stem cells in birth defects research and developmental toxicology / edited by Theodore P. Rasmussen.

Includes bibliographical references and index.

The Basics of Stem Cells and Their Utility as Platforms to Model Teratogen Action and Human Developmental and Degenerative Disorders / Bindu Prabhakar, Soowan Lee, and Theodore P. Rasmussen -- Stem Cells and Tissue Engineering Technologies for Advancing Human Teratogen Screening / Jiangwa Xing, Geetika Sahni and Yi-Chin Toh -- Use of Embryoid Bodies for the Detection of Teratogens and Analysis of Teratogenic Mechanisms / Anthony Flamier -- Stem-Cell-Based In vitro Morphogenesis Models to Investigate Developmental Toxicity of Chemical Exposures / Yusuke Marikawa -- RIsk Assessment Using Human Pluripotent Stem Cells: Recent Advances in Developmental Toxicity Screens / Kristen Buck and Nicole I. zur Nieden -- Modeling the Brain in the Culture Dish: Advancements and Applications of Induced Pluripotent Stem-Cell-Derived Neurons / Sandhya Chandrasekaran, Prashanth Rajarajan, Schahram Akbarian, and Kristen Brennand -- Modeling Genetic and Environment Interactions Relevant to Huntington's and Parkinson's Disease in Human Induced Pluripotent Stem Cells (hiPSCs)-Derived Neurons / Piyush Joshi, M. Diana Neely, and Aaron B. Bowman -- Alcohol Effects on Adult Neural Stem Cells - A Novel Mechanism of Neurotoxicity and Recovery in Alcohol Use Disorders / Rachael A. Olsufka, Hui Peng, Jessica S. Newton, and Kimberly Nixon -- Fetal Alcohol Spectrum Disorders: A Stem-Cellopathy? / Amanda H. Mahnke, Nihal A. Salem, Alexander M. Tseng, Annette S. Fincher, Andrew Klopfer, and Rajesh C. Miranda -- Toxicological Responses in Keratinocyte Interfollicular Stem Cells / Rambon Shamilov and Brian J. Aneskievich -- Stem-Cell Microscale Platforms for Toxicology Screening / Tiago G. Fernandes and Joaquim M. S. Cabral -- HepaRG Cells as a Model for Hepatotoxicity Studies / André Guillouzo and Christiane Guguen-Guillouzo.

This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders. Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology. Considers both in vitro uses of stem cells as platforms for teratology and also stem cellopathies, which are in vivo developmental and degenerative disorders. Helps the pharmaceutical industry and safety and environmental authorities validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives'--Provided by publisher.

Description based on online resource; title from digital title page (viewed on May 03, 2018).