DNA methylation and complex human disease / Michel Neidhart.

Includes bibliographical references and index.

''Front Cover'';''DNA Methylation and Complex Human Disease'';''Copyright Page'';''Contents'';''Preface'';''About the Author'';''1 DNA Methylation {u3848}? Introduction'';''1.1 Epigenetics'';''1.2 Histone Modifications'';''1.2.1 Histone Acetylation and Deacetylation'';''1.2.2 Histone Methylation'';''1.3 DNA Methylation'';''1.3.1 DNA Methyltransferases'';''1.4 Methyl-Binding Domain Proteins'';''1.5 DNA Demethylation'';''1.6 DNA Hydroxymethylation'';''1.7 Differentially Methylated Regions'';''1.8 Nutriepigenomics'';''References''

''2 DNA Methylation and Epigenetic Biomarkers in Cancer''''2.1 Introduction'';''2.1.1 Diagnosis Biomarkers'';''2.1.2 Progression Biomarkers'';''2.1.3 Predictive Biomarkers'';''2.1.4 Discovery of Novel Biomarkers'';''2.2 Cancerogenesis'';''2.3 Epimutations in Cancer'';''2.3.1 Esophageal Adenocarcinoma'';''2.3.2 Gastric Cancer'';''2.3.3 Colorectal Carcinoma'';''2.3.4 Lynch Syndrome'';''2.3.5 Endometrial and Ovarian Cancers'';''2.3.6 Lung Cancer'';''2.3.7 Glioblastoma'';''2.3.8 Hematopoietic Cancers'';''2.4 Conclusion'';''References''

''3 DNA Methylation and Epigenetic Biomarkers in Non-Neoplastic Diseases''''3.1 Introduction'';''3.2 Autoimmunity'';''3.2.1 Type 1 Diabetes'';''3.2.2 Rheumatoid Arthritis'';''3.2.3 Systemic Lupus Erythematosis'';''3.2.4 Inflammatory Bowel Disease, Crohn{u3848}?s Disease, and Ulcerative Colitis'';''3.3 Metabolic Diseases'';''3.3.1 Type 2 Diabetes'';''3.3.2 Heart Failure'';''3.4 Developmental Diseases'';''3.4.1 Imprinting Disorders'';''3.4.2 Arrhythmia'';''3.5 Psychiatric Diseases'';''3.5.1 Major Depressive Disorder'';''3.5.2 Schizophrenia'';''3.6 Conclusion'';''References''

''4 DNA Methylation and Environmental Factors''''4.1 Introduction'';''4.2 Impact of the Environment in Early Life'';''4.2.1 Genomic Imprinting'';''4.2.2 Beckwith-Wiedemann Syndrome'';''4.2.3 Assisted Reproductive Technologies'';''4.2.4 Large Offspring Syndrome'';''4.3 Nutritional Factors'';''4.3.1 Gestational Maternal Nutritional Factors'';''4.3.2 Nutritional Deficiencies'';''4.4 Adverse Environmental Factors'';''4.4.1 Environmental Toxicants'';''4.4.2 Ethanol Consumption'';''4.4.3 Smoking'';''4.5 Immune Activation'';''4.5.1 Asthma and Allergy'';''4.5.2 Bacterial Infections''

''4.5.3 Viral Infections''''4.6 Maternal Mood and Experience in Early Life'';''4.7 Physical Exercise'';''4.8 Conclusion'';''References'';''5 DNA Methylation and Epidemiology'';''5.1 Introduction'';''5.2 Endocrine Disrupting Chemicals'';''5.2.1 Bisphenol-A'';''5.2.2 Diethylstillbestrol'';''5.2.3 Cadmium'';''5.3 Epigenomics and Breast Cancer'';''5.3.1 RASSF1A'';''5.3.2 P16/CDKN2A'';''5.4 Tobacco Smoking'';''5.4.1 F2RL3, Smoking, and Cardiovascular Diseases'';''5.4.2 RUNX3, Smoking, Low Birth Weight, and Lung Carcinomas'';''5.4.3 AHRR, Smoking, and Lung Metastasis''

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylati.

Online resource; title from PDF title page (EBSCO, viewed August 20, 2015)

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