Systems biology in cancer research and drug discovery / Asfar S. Azmi, editor.

Includes bibliographical references and index.

pt. 1. Systems Biology in Cancer. Systems Biology Approach to Metabolomics in Cancer Studies / Mariano Bizzarri, Simona Dinicola and Cesare Manetti -- System Biology Approach to Study Cancer Related Pathways / Yike Guo and Xian Yang -- Modeling Oncogenic Signaling Networks from Gene Expression Dynamics / Aliccia Bollig-Fischer -- An Integrated Systems Approach to the Study of Pancreatic Cancer / Emanuela Gadaleta, Rosalind J. Cutts, Ajanthah Sangaralingam, Nicholas R. Lemoine and Claude Chelala -- Protein Microarray: An Ideal Platform for Systems Biology / Zong-Xiu Wang, Rui-Ping Deng, Shu-Juan Guo, Ji-Bin Zhang and Sheng-Ce Tao -- Systems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Development, Progression and Therapy Resistance / Sara Chiblak, Fevzi Demircioglu, Azadeh Fahim Golestaneh and Amir Abdollahi .

pt. 2. System Approaches to Understanding Cancer. Understanding Cancer Progression Using Protein Interaction Networks / Emre Guney, Rebeca Sanz-Pamplona, Angels Sierra and Baldo Oliva -- Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach / M. M. Quinas-Guerra, T. M. Ribeiro-Rodrigues, Juan Carlos Rodruez-Manzaneque and Rui D. M. Travasso -- Applications of Network Bioinformatics to Cancer Angiogenesis / Corban G. Rivera, Liang-Hui Chu, Joel S. Bader and Aleksander S. Popel .

pt. 3. Systems and Network Biology in Decoding miRNA Complexity. Human MicroRNA Targetome Indicates a Specialized Role of MicroRNAs in Regulation of Oncogenesis / Jun-ichi Satoh -- Novel and Alternative Bioinformatics Approaches to Understand miRNA-mRNA Interactome in Cancer Research / Xiaohong Li, Carolyn M. Klinge and Susmita Datta -- Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA-Target Dysregulated Network / Xia Li, Juan Xu and Yongsheng Li .

pt. 4. Network Modeling in Cancer Drug Discovery and Clinical Trials. Development and Clinical Implementation of Reverse Phase Protein Microarrays for Protein Network Activation Mapping: Personalized Cancer Therapy / Mariaelena Pierobon, Julie Wulfkuhle, Lance A. Liotta and Emanuel F. Petricoin III -- The Principle of Rational Design of Drug Combination and Personalized Therapy Based on Network Pharmacology / Jianghui Xiong, Simon Rayner, Fengji Liang and Yinghui Li -- Relevance of Network Hierarchy in Cancer Drug-Target Selection / Aritro Nath and Christina Chan -- Computational Infrastructures for Large-Scale Data Access and Analysis in Post-Genomic Clinical Trials / Manolis Tsiknakis -- Network Pharmacology: An Emerging Area in Anti-Cancer Drug Discovery / Asfar S. Azmi, Frances W. J. Beck, Bin Bao, Fazlul H. Sarkar and Ramzi M. Mohammad.

''Systems Biology in Cancer Research and Drug Discovery'' provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology in understanding aberrant signaling in cancer; in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways; in unwinding microRNAs complexity; and in anticancer drug discovery and in clinical trial design. This book revie