Microfluidics for medical applications /
edited by Albert van den Berg, University of Twente, Enschede, The Netherlands ; Loes Segerink, University of Twente, Enschede, The Netherlands.
- xvii, 303 pages : illustrations ; 24 cm.
- RSC Nanoscience & Nanotechnology ; No. 36 1757-7136, .
- RSC Nanoscience & Nanotechnology ; no. 36. .
Includes bibliographical references and index.
Microtechnologies in the Fabrication of Fibers for Tissue Engineering / Introduction -- Fiber Formation Techniques -- Co-axial Flow Systems -- Wetspinning -- Meltspinning (Extrusion) -- Electrospinning -- Conclusions -- Acknowledgements -- References -- Kidney on a Chip / Introduction -- Kidney Structure and Function -- Mimicking Kidney Environment -- Extracellular Matrix -- Mechanical Stimulation -- Various Kidney Cells -- Extracellular Environment -- Kidney on a Chip -- Microfluidic Approach for Kidney on a Chip -- Fabrication of Kidney on a Chip -- Various Kidney Chips -- Future Opportunities and Challenges -- References -- Blood-brain Barrier (BBB): An Overview of the Research of the Blood-brain Barrier Using Microfluidic Devices / Ali Khademhosseini -- Kahp-Yang Suh -- Albert van den Berg Machine generated contents note: ch. 1 1.1. 1.2. 1.2.1. 1.3. 1.4. 1.5. 1.6. ch. 2 2.1. 2.2. 2.3. 2.3.1. 2.3.2. 2.3.3. 2.3.4. 2.4. 2.4.1. 2.4.2. 2.4.3. 2.5. ch. 3 Introduction -- Blood-brain Barrier -- Neurovascular Unit -- Transport -- Multidrug Resistance -- Neurodegenerative Diseases -- Loss of BBB Function -- Modeling the BBB in Vitro -- Microfluidic in Vitro Models of the BBB: the'BBB-on-Chip' -- Cellular Engineering -- Biochemical Engineering -- Biophysical Engineering -- Measurement Techniques -- Transendothelial Electrical Resistance -- Permeability -- Fluorescence Microscopy -- Conclusion and Future Prospects -- Acknowledgements -- References -- The Use of Microfluidic-based Neuronal Cell Cultures to Study Alzheimer's Disease / Alzheimer's Disease -- Increased Mortality Rates and Still Incurable -- Unknowns of Alzheimer's Disease -- Molecular Key Players of AD -- From Molecules to Neuronal Networks -- Why Microsystems May Be a Key in Understanding the Propagation of AD -- Requirements for in Vitro Studies on AD Progression Philippe Renaud -- 3.1. 3.2. 3.2.1. 3.2.2. 3.2.3. 3.2.4. 3.3. 3.3.1. 3.3.2. 3.3.3. 3.3.4. 3.4. 3.4.1. 3.4.2. 3.4.3. 3.5. ch. 4 4.1. 4.2. 4.2.1. 4.2.2. 4.3. 4.3.1. Establishing Ordered Neuronal Cultures with Microfluidics -- Micro-devices-based in Vitro Alzheimer Models -- First Microtechnology-based Experimental Models -- Requirements of Future Micro-device-based Studies -- Questions that May Be Addressed by Micro-controlled Cultures -- References -- Microbubbles for Medical Applications / Introduction -- Microbubbles for Imaging -- Microbubbles for Therapy -- Microbubbles for Cleaning -- Microbubble Basics -- Microbubble Dynamics -- Microbubble Stability -- Microbubble Formation -- Microbubble Modeling and Characterization -- Optical Characterization -- Sorting Techniques -- Acoustical Characterization -- Conclusions -- Acknowledgements -- References -- Magnetic Particle Actuation in Stationary Microfluidics for Integrated Lab-on-Chip Biosensors / Introduction -- Capture of Analyte Using Magnetic Particles Michel Versluis -- Menno W. J. Prins -- 4.3.2. 4.4. 4.4.1. 4.4.2. 4.5. ch. 5 5.1. 5.1.1. 5.1.2. 5.1.3. 5.2. 5.2.1. 5.3. 5.4. 5.5. 5.5.1. 5.5.2. 5.5.3. 5.6. ch. 6 6.1. 6.2. The Analyte Capture Process -- Analyte Capture Using Magnetic Particles in a Static Fluid -- Analyte Detection -- Magnetic Particles as Carriers -- Agglutination Assay with Magnetic Particles -- Surface-binding Assay with Magnetic Particles as Labels -- Magnetic Stringency -- Integration of Magnetic Actuation Processes -- Conclusions -- Acknowledgements -- References -- Microfluidics for Assisted Reproductive Technologies / Introduction -- Gamete Manipulations -- Male Gamete Sorting -- Female Gamete Quality Assessment -- In Vitro Fertilization -- Cryopreservation -- Embryo Culture -- Embryo Analysis -- Conclusion -- References -- Microfluidic Diagnostics for Low-resource Settings: Improving Global Health without a Power Cord / Introduction: Need for Diagnostics in Low-resource Settings -- Importance of Diagnostic Testing -- Limitations in Low-resource Settings Shuichi Takayama -- Paul Yager -- 6.2.1. 6.2.2. 6.3. 6.3.1. 6.3.2. 6.3.3. 6.3.4. 6.4. 6.5. ch. 7 7.1. 7.2. 7.2.1. 7.2.2. 7.3. 7.4. 7.5. 7.6. 7.7. ch. 8 8.1. 8.1.1. 8.1.2. Scope of Chapter -- Types of Diagnostic Testing Needed in Low-resource Settings -- Diagnosing Disease -- Monitoring Disease -- Counterfeit Drug Testing -- Environmental Testing -- Overview of Microfluidic Diagnostics for Use at the Point of Care -- Channel-based Microfluidics -- Paper-based Microfluidics -- Enabling All Aspects of Diagnostic Testing in Low-resource Settings: Examples of and Opportunities for Microfluidics (Channel-based and Paper-based) -- Transportation and Storage of Devices in Low-resource Settings -- Specimen Collection -- Sample Preparation -- Running the Assay -- Signal Read-out -- Data Integration into Health Systems -- Disposal -- Conclusions -- References -- Isolation and Characterization of Circulating Tumor Cells / Introduction -- CTC Definition in CellSearch System -- Clinical Relevance of CTCs -- Identification of Treatment Targets on CTCs Leon W. M. M. Terstappen -- 8.1.3. 8.2. 8.2.1. 8.2.2. 8.2.3. 8.2.4. 8.3. 8.3.1. 8.3.2. 8.4. 8.4.1. 8.4.2. 8.4.3. 8.4.4. 8.4.5. 8.4.6. 8.4.7. 8.5. ch. 9 9.1. 9.2. 9.3. 9.4. Technologies for CTC Enumeration -- Isolation and Identification of CTCs in Microfluidic Devices -- Microfluidic Devices for CTC Isolation Based on Physical Properties -- Microfluidic Devices to Isolate CTCs Based on Immunological Properties -- Microfluidic Devices to Isolate CTCs Based on Physical as well as Immunological Properties -- Characterization of CTCs in Microfluidic Devices -- Summary and Outlook -- References -- Microfluidic Impedance Cytometry for Blood Cell Analysis / Introduction -- The Full Blood Count -- Clinical Diagnosis and the Full Blood Count -- Commercial FBC Devices -- Microfluidic Impedance Cytometry (MIC) -- Measurement Principle -- Behavior of Cells in AC fields -- Sizing Particles -- Cell Membrane Capacitance Measurements -- Microfluidic FBC Chip -- Accuracy and Resolution -- Antibody Detection -- Further Applications of MIC Daniel Spencer -- 9.5. 9.6. 9.6.1. 9.6.2. 9.6.3. 9.6.4. 9.7. ch. 10 10.1. 10.2. 10.2.1. 10.2.2. 10.3. 10.3.1. 10.3.2. 10.3.3. 10.3.4. 10.3.5. 10.3.6. 10.3.7. 10.4. Cell Counting and Viability -- Parasitized Cells -- Tumor Cells and Stem Cell Morphology -- High-frequency Measurements -- Future Challenges -- References -- Routine Clinical Laboratory Diagnostics Using Point of Care or Lab on a Chip Technology / Introduction -- Point-of-care Testing -- Categorization of POCT Devices -- Role of POCT in Laboratory Medicine -- Glucometers -- The WHO and ADA Criteria of Diabetes -- Plasma Glucose or Blood Glucose -- Glucometers in Medical Practice -- Glucometers in Gestational Diabetes -- Continuous Glucose Monitoring -- i-STAT: a Multi-parameter Unit-use POCT Instrument -- Clinical Chemistry -- Cardiac Markers -- Hematology -- Clinical Use and Performance -- Conclusions -- References -- Medimate Minilab, a Microchip Capillary Electrophoresis Self-test Platform / Introduction Istvan Vermes -- Jan C. T. Eijkel -- 10.4.1. 10.4.2. 10.4.3. 10.4.4. 10.5. ch. 11 11.1. 11.2. 11.2.1. 11.2.2. 11.3. 11.3.1. 11.3.2. 11.3.3. 11.3.4. 11.3.5. 11.4. 11.4.1. 11.4.2. 11.4.3. 11.4.4. 11.5. ch. 12 12.1. Microfluidic Capillary Electrophoresis as a Self-test Platform -- Conducting a Measurement -- Measurement Process -- From Research Technology to Self-test Platform -- A Lithium Self-test for Patients with Manic Depressive Illness -- Validation Method -- Applied Guidelines -- Acceptance Criteria -- Sample Availability, Preparation, and other Considerations -- Validation Results -- Reproducibility -- Linearity -- Method Comparison -- Home Test -- Other Study Results -- Final Evaluation -- Platform Potential -- Current Platform Capabilities -- Future Possibilities and Limitations -- Conclusions -- Acknowledgements -- References. 12.2. 12.2.1. 12.2.2. 12.2.3. 12.3. 12.4. 12.4.1. 12.4.2. 12.4.3. 12.5. 12.5.1. 12.5.2. 12.5.3. 12.5.4. 12.5.5. 12.5.6. 12.6. 12.6.1. 12.6.2. 12.7.