TY  - BOOK
AU  - Vaughan,Tristan
AU  - Osbourn,Jane
AU  - Jallal,Bahija
TI  - Protein therapeutics
T2  - Methods and principles in medicinal chemistry
SN  - 9783527699131
AV  - RM666.P87 
U1  - 615.3 23
PY  - 2017///]
CY  - Weinheim, Germany
PB  - Wiley-VCH
KW  - Protein drugs
KW  - Proteins
KW  - Therapeutic use
KW  - MEDICAL / Pharmacology
KW  - bisacsh
KW  - fast
KW  - Electronic books
N1  - Includes bibliographical references and index; Cover ; Title Page ; Copyright ; Contents; Preface ; A Personal Foreword ; Acknowledgments ; Volume 1; Part I Introduction to Protein Therapeutics: Past and Present ; Chapter 1 Early Recombinant Protein Therapeutics ; 1.1 Introduction ; 1.2 The Birth of Genetic Engineering; 1.3 Recombinant Human Insulin 1.3.1 The Race to Clone the Human Insulin Gene and to Produce Human Recombinant Insulin ; 1.3.2 Novo's Counter Strategy: Semisynthetic Human Insulin ; 1.3.3 Yeast Recombinant Insulin ; 1.4 Recombinant Human Growth Hormone ; 1.5 Recombinant Human Interferons; 1.6 Recombinant Human Erythropoietin 1.7 Recombinant Tissue -- Type Plasminogen Activator ; 1.8 Recombinant Hepatitis B Virus (HBV) Vaccine ; 1.9 Postscript ; Acknowledgments ; References ; Chapter 2 Evolution of Antibody Therapeutics; 2.1 Overview of Antibody Therapeutics Development 2.2 Polyclonal Antibodies -- Laying the Foundation for mAb Therapy ; 2.3 Evolution of Monoclonal Antibody Therapeutics ; 2.3.1 Chimeric and Humanized mAbs ; 2.3.2 Fully Human Antibodies ; 2.4 Fc Fusion Proteins; 2.5 Evolution of Concepts in Antibody Pharmacology 2.5.1 Neutralization ; 2.5.2 From Killing Bacteria to Killing Human Cells ; 2.5.3 Targeting Membrane Receptors ; 2.6 Future Directions for Antibody Therapeutics Development ; Acknowledgments ; References
N2  - In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed
UR  - https://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9783527699124
ER  -