TY  - BOOK
AU  - Handler,Norbert
AU  - Buschmann,Helmut
TI  - Drug selectivity: an evolving concept in medicinal chemistry 
T2  - Methods and principles in medicinal chemistry
SN  - 9783527674411
AV  - RM300 
U1  - 615.1 23
PY  - 2018///]
CY  - Weinheim, Germany
PB  - Wiley-VCH
KW  - Drugs
KW  - Effectiveness
KW  - MEDICAL
KW  - Pharmacology
KW  - bisacsh
KW  - fast
KW  - Drug Design
KW  - Chemistry, Pharmaceutical
KW  - Pharmaceutical preparations
KW  - Electronic books
KW  - Electronic book
N1  - Includes bibliographical references and index; Introduction. Polypharmacology in Drug Discovery / Oscar Méndez-Lucio, J Jesús Naveja, Hugo Vite-Caritino, Fernando D Prieto-Martínez, José L Medina-Franco -- Selectivity of Marketed Drugs. Kinase Inhibitors / Peng Wu, Michael Givskov, Thomas E Nielsen -- Repositioning of Drug -- New Indications for Marketed Drugs / Ren Kong, Stephen T Wong -- Discovery Technologies for Drug Repurposing / Naiem T Issa, Stephen W Byers, Sivanesan Dakshanamurthy -- Unselective Drugs in Drug Discovery. Personalized Medicine / Christian Noe, Volker Baumann -- Drug Discovery Strategies for the Generation of Multitarget Ligands against Neglected Tropical Diseases / Annachiara Gandini, Federica Prati, Elisa Uliassi, Maria L Bolognesi -- Designing Approaches to Multitarget Drugs / Luca Costantino, Daniela Barlocco -- The Linker Approach / Daniel Merk, Manfred Schubert-Zsilavecz -- Merged Multiple Ligands / Hongming Chen, Udo Bauer, Ola Engkvist -- Pharmacophore Generation for Multiple Ligands / Norbert Handler -- Cellular Assays / Ye Fang -- Therapeutic Areas for Designed Multiple Ligands. Developing Serotonergic Antidepressants Acting on More Than the Serotonin Transporter / Gerard J Marek -- Multiple Ligands Targeting the Angiotensin System for Hypertension / Agustin Casimiro-Garcia -- Multiple Peroxisome Proliferator-Activated Receptor-Based Ligands / Dmytro Kukhtar, Miquel Mulero, Raul Beltrán-Debón, Cristina Valls, Gerard Pujadas, Santiago Garcia-Vallve -- Antibiotics / Jean-Philippe Surivet, Philippe Panchaud -- Multiple Ligands in Neurodegenerative Diseases / Julien Lalut, Christophe Rochais, Patrick Dallemagne
UR  - https://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9783527674381
ER  -