Drug selectivity :  an evolving concept in medicinal chemistry / 
edited by Norbert Handler and Helmut Buschmann. 
 - 1 online resource. 
 - Methods and principles in medicinal chemistry ;  v. 72 .
 - Methods and principles in medicinal chemistry ;  v. 72. .
<br/><br/>Includes bibliographical references and index. 
<br/><br/>Introduction. Polypharmacology in Drug Discovery / Oscar Méndez-Lucio, J Jesús Naveja, Hugo Vite-Caritino, Fernando D Prieto-Martínez, José L Medina-Franco -- Selectivity of Marketed Drugs. Kinase Inhibitors / Peng Wu, Michael Givskov, Thomas E Nielsen -- Repositioning of Drug -- New Indications for Marketed Drugs / Ren Kong, Stephen T Wong -- Discovery Technologies for Drug Repurposing / Naiem T Issa, Stephen W Byers, Sivanesan Dakshanamurthy -- Unselective Drugs in Drug Discovery. Personalized Medicine / Christian Noe, Volker Baumann -- Drug Discovery Strategies for the Generation of Multitarget Ligands against Neglected Tropical Diseases / Annachiara Gandini, Federica Prati, Elisa Uliassi, Maria L Bolognesi -- Designing Approaches to Multitarget Drugs / Luca Costantino, Daniela Barlocco -- The Linker Approach / Daniel Merk, Manfred Schubert-Zsilavecz -- Merged Multiple Ligands / Hongming Chen, Udo Bauer, Ola Engkvist -- Pharmacophore Generation for Multiple Ligands / Norbert Handler -- Cellular Assays / Ye Fang -- Therapeutic Areas for Designed Multiple Ligands. Developing Serotonergic Antidepressants Acting on More Than the Serotonin Transporter / Gerard J Marek -- Multiple Ligands Targeting the Angiotensin System for Hypertension / Agustin Casimiro-Garcia -- Multiple Peroxisome Proliferator-Activated Receptor-Based Ligands / Dmytro Kukhtar, Miquel Mulero, Raul Beltrán-Debón, Cristina Valls, Gerard Pujadas, Santiago Garcia-Vallve -- Antibiotics / Jean-Philippe Surivet, Philippe Panchaud -- Multiple Ligands in Neurodegenerative Diseases / Julien Lalut, Christophe Rochais, Patrick Dallemagne. 
<br/><br/><label>ISBN: </label>9783527674411 3527674411 9783527674381 3527674381 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Drugs--Effectiveness.<br/>MEDICAL--Pharmacology.<br/>Drugs--Effectiveness.<br/>Drug Design.<br/>Chemistry, Pharmaceutical.<br/>Pharmaceutical preparations.
<br/><br/><label>Index Terms--Genre/Form: </label><br/>Electronic books.<br/>Electronic book.
<br/><br/><label>LC Class. No.: </label>RM300 
<br/><br/><label>Dewey Class. No.: </label>615.1 
<br/><br/><label>National Library of Medicine Call No.: </label>W1  / ME9613H v.72 2018 QV 745