TY  - BOOK
AU  - Pfannkuch,Friedlieb
AU  - Suter-Dick,Laura
TI  - Predictive toxicology: from vision to reality 
T2  - Methods and principles in medicinal chemistry
SN  - 9783527336081 (hd.bd. : alk. paper)
PY  - 2015///]
CY  - Weinheim
PB  - Wiley-VCH
KW  - Toxicology
KW  - Drugs
KW  - Toxicity testing
KW  - Drug development
KW  - Safety measures
N1  - Includes bibliographical references and index; Introduction to Predictive Toxicology Tools and Methods / Laura Suter-Dick and Friedlieb Pfannkuch -- In silico toxicology : Current Approaches and Future Perspectives to Predict Toxic Effects with Computational Tools / Thomas Steger-Hartmann -- In silico approaches: Data Management : Bioinformatics / Arnd Brandenburg, Hans Gmuender, and Timo Wittenberger -- Role of Modeling and Simulation in Toxicology Prediction / Antje-Christine Walz, Hans Peter Grimm, Christophe Meille, Antonello Caruso, Neil Parrott, and Thierry Lav-- Genomic Applications for Assessing Toxicities of Liver and Kidney Injury / Philip Hewitt and Esther Johann -- Use of Toxicogenomics for Mechanistic Characterization of Hepatocarcinogens in Shorter Term Studies / Heidrun Ellinger-Ziegelbauer -- Discovery and Application of Novel Biomarkers / Timothy W. Gant, Emma L. Marczylo, and Martin O. Leonard -- Predictive Toxicology: Genetics, Genomics, Epigenetics, and Next-Generation Sequencing in Toxicology / Tobias Heckel and Laura Suter-Dick -- Biomarkers as Tools for Predictive Safety Assessment: Novel Markers of Drug-Induced Kidney Injury / Angela Mally -- The Use of Renal Cell Culture for Nephrotoxicity Investigations / Anja Wilmes and Paul Jennings -- The Zebrafish Model in Toxicology / Natalie Mesens -- Predictive Method Development: Challenges for Cosmetics and Genotoxicity as a Case Study / Gladys Ouraogo, Fabrice Nesslany, Sophie Simar, Smail Talahari, Doris Lagache, Eric Vercauteren, Lauren Nakab, Astrid Mayoux, Brigitte Faquet, and Nicole Flamand -- Using Pluripotent Stem Cells and Their Progeny as an in vitro Model to Assess (Developmental) Neurotoxicity / Lisa Hoelting, Marcel Leist, and Luc Stoppini -- Stem Cell-Based Methods for Identifying Developmental Toxicity Potential / Jessica A. Palmer, Robert E. Burrier, Laura A. Egnash, and Elizabeth L.R. Donley -- Immunogenicity of Protein Therapeutics: Risk Assessment and Risk Mitigation / Harald Kropshofer -- Regulatory Aspects / Beatriz Silva Lima
ER  -