TY  - BOOK
AU  - Azmi,Asfar S.
TI  - Systems biology in cancer research and drug discovery
SN  - 9789400748187 (hbk.)
PY  - 2012///
CY  - Dordrecht
PB  - Springer
KW  - Cancer
KW  - Research
KW  - Systems Biology
KW  - Drug development
KW  - Drugs
KW  - Design
KW  - Pharmacy
KW  - Technological innovations
N1  - Includes bibliographical references and index; pt. 1; Systems Biology in Cancer; Systems Biology Approach to Metabolomics in Cancer Studies; Mariano Bizzarri, Simona Dinicola and Cesare Manetti --; System Biology Approach to Study Cancer Related Pathways; Yike Guo and Xian Yang --; Modeling Oncogenic Signaling Networks from Gene Expression Dynamics; Aliccia Bollig-Fischer --; An Integrated Systems Approach to the Study of Pancreatic Cancer; Emanuela Gadaleta, Rosalind J. Cutts, Ajanthah Sangaralingam, Nicholas R. Lemoine and Claude Chelala --; Protein Microarray: An Ideal Platform for Systems Biology; Zong-Xiu Wang, Rui-Ping Deng, Shu-Juan Guo, Ji-Bin Zhang and Sheng-Ce Tao --; Systems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Development, Progression and Therapy Resistance; Sara Chiblak, Fevzi Demircioglu, Azadeh Fahim Golestaneh and Amir Abdollahi; pt. 2; System Approaches to Understanding Cancer; Understanding Cancer Progression Using Protein Interaction Networks; Emre Guney, Rebeca Sanz-Pamplona, Angels Sierra and Baldo Oliva --; Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach; M. M. Quinas-Guerra, T. M. Ribeiro-Rodrigues, Juan Carlos Rodruez-Manzaneque and Rui D. M. Travasso --; Applications of Network Bioinformatics to Cancer Angiogenesis; Corban G. Rivera, Liang-Hui Chu, Joel S. Bader and Aleksander S. Popel; pt. 3; Systems and Network Biology in Decoding miRNA Complexity; Human MicroRNA Targetome Indicates a Specialized Role of MicroRNAs in Regulation of Oncogenesis; Jun-ichi Satoh --; Novel and Alternative Bioinformatics Approaches to Understand miRNA-mRNA Interactome in Cancer Research; Xiaohong Li, Carolyn M. Klinge and Susmita Datta --; Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA-Target Dysregulated Network; Xia Li, Juan Xu and Yongsheng Li; pt. 4; Network Modeling in Cancer Drug Discovery and Clinical Trials; Development and Clinical Implementation of Reverse Phase Protein Microarrays for Protein Network Activation Mapping: Personalized Cancer Therapy; Mariaelena Pierobon, Julie Wulfkuhle, Lance A. Liotta and Emanuel F. Petricoin III --; The Principle of Rational Design of Drug Combination and Personalized Therapy Based on Network Pharmacology; Jianghui Xiong, Simon Rayner, Fengji Liang and Yinghui Li --; Relevance of Network Hierarchy in Cancer Drug-Target Selection; Aritro Nath and Christina Chan --; Computational Infrastructures for Large-Scale Data Access and Analysis in Post-Genomic Clinical Trials; Manolis Tsiknakis --; Network Pharmacology: An Emerging Area in Anti-Cancer Drug Discovery; Asfar S. Azmi, Frances W. J. Beck, Bin Bao, Fazlul H. Sarkar and Ramzi M. Mohammad
N2  - ''Systems Biology in Cancer Research and Drug Discovery'' provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology in understanding aberrant signaling in cancer; in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways; in unwinding microRNAs complexity; and in anticancer drug discovery and in clinical trial design. This book revie
ER  -