Chemistry of protein and nucleic acid cross-linking and conjugation /
Shan S. Wong and David M. Jameson.
- 2nd ed.
- Boca Raton : CRC Press, c2012.
- xvii, 602 p. : ill. ; 27 cm.
Rev. ed. of: Chemistry of protein conjugation and cross-linking. c1991.
Includes bibliographical references and index.
Overview of protein conjugation -- Review of protein and nucleic acid chemistry -- Reagents targeted to specific functional groups -- How to design and choose cross-linking reagents -- Homobifunctional cross-linking reagents -- Heterobifunctional cross-linkers -- Multifunctional cross-linking reagents -- Monofunctional and zero-length cross-linking reagents -- General approaches for chemical cross-linking -- Analysis of cross-linked products -- Applications of chemical cross-linking to the study of biological macromolecules -- Applications of chemical conjugation in the preparation of immunoconjugates and immunogens -- Application of chemical conjugation for the preparation of immunotoxins and other drug conjugates for targeting theraputics.