TY  - BOOK
AU  - Smith,Dennis A.
ED  - Royal Society of Chemistry (Great Britain)
TI  - Metabolism, pharmacokinetics, and toxicity of functional groups: impact of the building blocks of medicinal chemistry in ADMET 
T2  - RSC drug discovery series,
SN  - 9781849730167 (hbk.)
PY  - 2010///
CY  - Cambridge, [England]
PB  - Royal Society of Chemistry
KW  - Pharmacokinetics
KW  - Chemistry, Pharmaceutical
KW  - methods
KW  - Pharmaceutical Preparations
KW  - metabolism
N1  - Drugs and their structural motifs -- ADMET for the medicinal chemist -- Carboxylic acids and their bioisosteres -- Primary, secondary, and tertiary amines and their isosteres -- Sulfonamide as an essential functional group in drug design -- Influence of aromatic rings on ADME properties of drugs -- Influence of heteroaromatic rings on ADME properties -- Peptidomimetics and peptides as drugs: motifs incorporated to enhance drug characteristics -- Pharmacokinetics and metabolism of compounds that mimic enzyme transition states -- Alcohols and phenols: absorption, distribution, metabolism, and excretion -- Future targets and chemistry and ADME needs
ER  -