Metabolism, pharmacokinetics, and toxicity of functional groups : impact of the building blocks of medicinal chemistry in ADMET - Smith, Dennis A.; Royal Society of Chemistry (Great Britain) (Cambridge, [England] : Royal Society of Chemistry, 2010)
Drugs and their structural motifs -- ADMET for the medicinal chemist -- Carboxylic acids and their bioisosteres -- Primary, secondary, and tertiary amines and their isosteres -- Sulfonamide as an essential functional group in drug design -- Influence of aromatic rings on ADME properties of drugs -- Influence of heteroaromatic rings on ADME properties -- Peptidomimetics and peptides as drugs: motifs incorporated to enhance drug characteristics -- Pharmacokinetics and metabolism of compounds that mimic enzyme transition states -- Alcohols and phenols: absorption, distribution, metabolism, and excretion -- Future targets and chemistry and ADME needs
Keywords: Pharmacokinetics; Chemistry, Pharmaceutical -- methods; Pharmaceutical Preparations -- metabolism