What's wrong with my mouse? : behavioral phenotyping of transgenic and knockout mice /
Jacqueline N. Crawley
- 2nd ed.
- Hoboken, N.J. : John Wiley, 2007
- xvi, 523 p. : ill. ; 26 cm.
Designer mice : scope and sourcebooks -- Of unicorns and chimeras : how to generate a transgenic or knockout mouse -- General health : give your mouse a physical -- Motor functions : open field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures -- Sensory abilities : olfaction, vision, hearing, taste, touch, nociception -- Learning and memory : Morris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning -- Feeding and drinking : daily consumption, restricted access, choice tests, microstructural analysis -- Reproductive behaviors : sexual and parental behaviors -- Social behaviors : social interaction, nesting, grooming, juvenile play, aggression -- Emotional behaviors : animal models of psychiatric disorders : fear, anxiety, depression, schizophrenia -- Reward : self-administration of addictive drugs, conditioned place preference -- The next generation : conditional and inducible mutations, quantitative trait loci analysis, chemical mutagenesis, gene therapy, ethical issues -- Putting it all together -- The next generation : conditional and inducible transgenics and knockouts