Bladder cancer : risk factors, emerging treatment strategies and challenges / Samantha Haggerty, editor.

Includes bibliographical references and index.

Cancer stem cell (CSC) in bladder malignancy / Jianmin Zhang (and two others) -- The five senses in bladder cancer diagnostics / Caterina Gulia (and four others) -- Bladder cancer in pediatric patients / Santiago Vallasciani (and four others) -- Multi-tasking chemoinformatic model for the efficient discovery of potent and safer anti-bladder cancer agents / Alejandro Speck-Planche and M. N. D. S. Cordeiro -- Long non coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer / Jamie Villegas (and ten others) -- Histological variants of urothelial carcinoma / Hyung Suk Kin and Ja Hyeon Ku -- Novel therapeutic modalities in patients with advanced or metastatic urothelial carcinoma / Kazumasa Matsumoto (and four others).

Bladder cancer is the fifth most common form of cancer worldwide and is mainly prevalent in developed countries. It is thought to arise through two distinct pathways: the noninvasive and the invasive. The noninvasive pathway gives rise to a superficial papillary carcinoma that is characterized by activating mutations in oncogenes such as H-ras, FGFR3 and PI3K. This pathway is rarely lethal as superficial papillary carcinomas can be readily removed through transurethral resection. However, 15% of noninvasive urothelial tumors can transform into invasive carcinomas and have high recurrence 80%.-- Source other than Library of Congress.